Definitely. Some of them are simply never going to accept it. They actually have nothing on some of the craziest real person shippers out there. I remember reading somewhere that some Louis Tomlinson/Harry Styles shippers were so convinced of Louis Tomlinson's baby not being real that one stalker tweeted she was going to prove it was a doll by tipping it out of its pram. I'm not sure if they still believe it, but I remember a bunch of Sherlock/Benedict Cumberbatch fans also thought his wife/baby weren't 'real' when he first got engaged.
And then there's a small group of Sam Hueghan/Caitriona Balfe shippers, who think that they're secretly married with three secret children, despite her actually being married with one child to a guy she was engaged to before Outlander even started.
Rose/Gio shippers are barely even on board the crazy train in the grand scheme of things!