I've only ever tried cannabis and I didn't like the effect at all. I'm a registered nurse and illicit drug taking is not approved of, funnily enough. I has class A's during labour (the process, not the political party) but really didn't appreciate it at the time
Working in showbiz though, there are so many opportunities to get hold of stuff.
It must be difficult to refuse the offer of something that's going to perk you up and make you feel refreshed and intensely happy.
Alcohol is my drug of choice, perfectly legal and easy to get shitfaced if that's what I want. Mostly though, it's a glass or two with a meal on my days off.