I like to think so too H of CPterry would have never, ever let her use his work. Would have seen through her straight away.
Rihanna has made a big mistake letting her use the quote.
Ooh, is this why redheads sometimes need more anaesthesia?? Fascinating!Ooh yes pharmacogenetics is super interesting!
It’s not something I’ve studied in depth yet but I know we have a module this term which will cover more of this which I’m excited for, but what I know is that there are a whole range of factors which determine the way your body metabolizes drugs, eg your sex, age, weight, race, kidney function, hepatic function etc. and your individual genetic make up also definitely plays a huge part in the way your body reacts to drugs.
Some people have mutations in the genes which code for enzymes in the cytochrome P450 family which are responsible for the metabolism of many substances, and these mutations can change the speed of which they metabolize certain drugs. An example off the top of my head is the CYP2C19 enzyme, which is responsible for metabolizing quite a lot of common medications such as amitriptyline, sertraline and citalopram, as well as omeprazole and clopidogrel. Depending on which mutations you have to this enzyme, your body will either speed up the metabolization process of the drugs which it breaks down, or it could slow it down. This generally means that you’ll need either a higher or lower dose of medication, and it can also mean that you suffer worse/fewer side effects compared to someone who has normal enzyme function.
That’s just one example of a particular enzyme that we know of, but drug metabolism is a super complex process, there are countless enzymes involved. We can find out if someone has one of these genetic mutations and is therefore a rapid/slow metabolizer through genetic testing, but that’s quite expensive and I don’t think they offer it on the NHS.
So yeah, tldr it’s really difficult to know in advance how any drug will effect any individual because of a multitude of factors including genetics! That said, genome sequencing is becoming cheaper every year and our knowledge of genetics is constantly expanding, so who knows, hopefully in the future we might actually have an inexpensive test to determine exactly how someone will react to a drug in advance so we can somewhat avoid the annoying trial and error period that many have to deal with in order to find the right medication for them!
Sleeping on a sofa won't have helped
It is that one, yep!Two things.
1. I take it the squig who posted last night about the refund isn’t ~the~ refund squig who keeps talking about small claims court?
The other most persist and long-standing refund seeker who posts periodic updates of the lack of refund has said that she is going to pursue the same tactics. Part of me hopes that each one takes it in turn so there’s a long drip-feed of this. Still probably won’t make her lobotomised FMs think; hellsite search is looking beautiful though.It is that one, yep!
Careful. She'll be on later saying it has out performed expectations and ACTUALLY we've helped her sales. Toot toot wildest dreams etc.She won't be able to stand her book bombing when others in the same genre are flying. It will cause her deep narcissistic injury. This is why she isn't promoting it, seeing it flop is pain enough for her. The ridicule surrounding the "tips" will amplify the injury tenfold. This is also why she's returning to type, snark, aggression, threats, pretend ailments. Anything to change the narrative and ease the pain
Title thread nomination!Jack is the Evri of cooking; unreliable, steals and rarely delivers.
I’m repeating myself like a ninny but as far as I can see, he isn’t representing her in a talent management sense, just if you want to book her for a speaking event, you do it through him. So a passive rather than active agent if you will and it doesn’t cost him anything to have her on the books.What will it take for Adrian the agent to drop her? Will agents keep clients on if they're not bringing in the £s?
Am I right in thinking Jack has ignored others who asked; but this squig mentioned it on a blue tick comment to Jack and then she was all over it?Glad the small claims court squig got her money back. It sets a precedence. Jack knows how to do it, she's proven that. The lying bitch has probably always known. Let the flood gates open! It would be great if the squig could post links to advice on how to do it and what the steps were for others to follow.
Remember that nonsense tweet a few days ago - she said she chose that sofa years ago specifically thinking about the future when she might have to permanently sleep on it due to arthritis. Balls. No sofa ever will offer the support a bed can, especially if you are in pain.Sleeping on a sofa won't have helped
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