I've been anemic all my life just about and find for me they take about 3 weeks to make any difference, but I know with some people they can work much faster. I have to take mine with food (nothing with dairy though as it can stop absorption!) Otherwise I feel so sick and get really constipated. Orange juice is supposedly great to take them with as mentioned but I HATE oranges so I just try and take them with some form of fruit aswell.I got diagnosed with iron deficiency anemia 2 days ago, just curious how long it took for the tablets to start making you feel better? I can't wait to hopefully not feel tired all the time anymore!