She (like many others, statistician Richard Gill included) believes this idiot who claims to be a scientist and said that Hindmarsh incorrectly calculated the amount of insulin required to produce the steady state plasma concentration of 4656 pmol/L of insulin observed in baby F. He thinks she would have needed to put just over 10mL (1000 units of insulin) into each TPN bag to produce that (20 mL in total if she contaminated 2).Not medical, can you explain that please, I love learning about the how’s or why’s. That’s the difference between us here and others, we are willing to learn and investigate to form an opinion.![]()
The expert witnesses say that it would have taken 1.8 units of insulin per hour to produce that concentration, so depending on how long the TPN was run for (let’s say 24 hr) she would have only needed to put just shy of 0.5 mL into the TPN (1.8 x 24 = 43.2 units, each mL of insulin contains 100 units, so 0.432 mL) if she contaminated 2 bags then she’d have only needed 1mL or slightly less.
The clown scientist has finally released the full calculation and it’s as I said it would be, completely wrong because they don’t understand how to convert between units. Also I have no idea where tf they got their data from either.
here is the correct calculation, apologies for the weird decimal points and messy hand writing (unfortunately I didn’t have time to make a 27 page report or a fancy flow diagram either
![Face with rolling eyes :rolling_eyes: 🙄](https://cdn.jsdelivr.net/gh/joypixels/emoji-assets@5.0/png/64/1f644.png)
The reason why I’ve calculated 1.5 IU rather than the 1.8 hindmarsh got is because hindmarsh would have likely used pharmacokinetic data for neonates, where as I’ve used the data I can find online for insulin pharmacokinetics in adults. This data is the distribution volume and the half life, however these parameters vary in ‘special’ populations (e.g neonates, children, geriatric patients, those with renal insufficiency etc) and distribution volume in particular tends to be different in neonates. Hindmarsh would have accounted for this difference in his calculation, I haven’t because as I say, I couldn’t find any data for it and I’m not an expert. However, as you can see, more or less the same result and certainly not 44IU per hour like this fool has suggested.