One thing I find interesting - and I may be wrong, because I certainly havent seen or read all of them - is that while Ioan was always over the moon praising Alice in the press during their relationship, he never even once mentioned her physical struggles. Might be because he is discreet (though he did mention her having IVF before she apparently wanted it to be known), but it might be also telling that he who probably knows the most about her condition, medical records and how she dealt with it, didnt quite believe her or at least wasnt too impressed.
Alice mentioned in that fibro forum that she searched 7 years for a doctor that would be willing to accept that she has something, doctors would have before that reassured her that she is the healthiest person they ever met etc. I dont think that it's a coincidence that her appearance and behavior rapidly declined (and it really fits exactly, even if other things happened at the same time too) as soon as she had "confirmation" that she had something, it's quite common, a self-fullfilling prophecy so to speak: once you know you have something many people let themselves down, and thus they develop patterns that actually cause worse symptoms or develop an more dangerous disease that way (or develop a disease in the first place if you actually didnt had something initially). Our thinking massively impacts our health.
This is obviously not saying that she doesnt have anything (although, duck me, she drives me nuts with her "I think I had every disease under the sun without knowing" shtick just to score extra points), in fact, it's rather unusual if a middle aged women didnt had physical struggles. But the way you think about this stuff and how you approach it make a massive difference to how managable the pain is. And this - and I repeat myself - brings us yet again back to the difference between the two women. I'm generally dont be an advocate of this all positive thinking, but for this stuff it's totally the only way.
ETA: Interestingly enough Alice's latest post has way more likes after such a short time than anything she had for a while, obviously still very low for an account of that follower count, but I guess she has woken up her "supporters" with the amount of posts recently - on time to defend her for what is (possibly) to come in a few weeks. Her posts recently are definitely in parts aimed to establish a counter narrative.