re: depression. You can pinpoint pretty well when her mental well-being, her social media addiction and her issues with her taking care of her body/health went south: it's when Ioan was away for a long time and she increasingly lived her life through twitter (approx early 2019), pandemic and menopause will not have helped this either. However, her behavior online became already before that increasingly erratic, and it was already problematic over 15 years ago (those who were actively involved will know better, but I remember allegations of quite serious threats). And it still can't excuse how far she has been willing to go in order to destroy the father of her kids and anyone that remotely supports him. While there are certainly mental health issues involved (which I hope will improve due to her being not allowed to be toxic in public, sadly I fear though she lives that side still through other means) it's not the whole story with her. A lot of it is just her being her. However, I wouldn't be too surprised if she is entering a rather dark phase due to her realizing that there is no turning back now and that her life will not be (relatively) blissfully easy as it was until now. Even the worst people have this.
As for him: always hard to say from the distance. He certainly was depressed over his own dillema (continue to live through a nightmare for the kids sake, or escaping and leaving a mess behind). I wouldn't be surprised if he has issues to that contribute to him currently not taking the most painful route, just to not continue to be eaten by pain. Who knows. He certainly looked horrible the last year with Alice (which was the first in a long time with her) and he looked unhealthy almost every time he got papped since she started kicking off. It's only since the TRO that he looks really proper happy.