Food & Drink #9 Vlad likes traazers on a bird

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So how the duck will they make a vaccine if a vaccine IS anti bodies? Does anyone else feel like they’re gonna end up like will smith in I am legend?
Massively over the top paragraphs below because i genuinely find this interesting and wish i had more time to read up on it. (This is coming from like...nearly a decade old a level biology and a couple of podcasts/sciencey websites i read, so if anyone has more current and in depth knowledge in virology from their job or degree etc feel free to step in and save me from my ignorance)

From what i understand vaccines are either a weakened/dead strain of the virus in question (flu shot) or another virus so similar that the immune system thinks theyre the same disease and will react to the actual virus we want to stop (cowpox to smallpox)

Our bodies produce antibodies to fight disease. They do duck all at the time of actually getting the disease to stop you catching it, but if virus enters your body, something starts cranking these antibodies in trial and error until it works out a shape that fits the virus. Antibodies are all pretty much shaped like the letter Y though and its top two bits are like hands, which grab onto the virus. If the white blood cells see anything covered in antibodies they know its bad news and go in for the kill.

So the first time you get a disease theres a lot of time spent making the exact shape of antibody specialised for this virus but the SECOND time the virus moseys on into your body, your body is like

"its that little tit who made us too sick to go to the work xmas do last year! Get him lads!"

and we already have the 'factories' for that shape of antibodies in place, so it rattles them out much quicker. A bit like a car factory, once they have all the equipment to make a vauxhall corsa or whatever they can just start firing them out, but if they suddenly get told "we need to make ferraris" it might take a while to get a new factory with all the equipment and machine lines up and running. A chickenpox antibody would look at covid and just go "pfft. Not my job."

The flu gets round this by mutating and changing all the time (basically it puts on different glasses and a silly hat), so the science boffins have to basically guess (im sure theres a good analytical model rather than a pure guess) which version of the flu will be round at xmas time, and if they get it wrong you can still get the flu which is why some people still get sick.

And obviously there can be issues when some people's bodies are a bit paranoid and start labelling everything as an intruder - whacking antibodies on completely harmless cells like say, one's own liver, and then the white blood cells start attacking your own body - which is one reason why some people may have to take immunosuppressants - and then with the immune system knocked out theyre vulnerable to genuine threats

It is normal for some immunity loss over time for a lot of diseases (imagine the corsa factories havent needed to make a single corsa in 2 years, body's just like nah clear off we're gonna close most of you and build some overpriced student flats here instead) The weird thing about covid is that the body is maybe shutting down the antibody 'factories' within like 2/3 months which is ridiculouslyquick ???

So people could get it again and body would have to start from scratch making the covid antibody shape again.

I know its a completely new virus so its all up in the air, and my science knowledge is nowhere near deep enough to know WHY antibodies being lost so fast, but i know it means "herd immunity" is not happening now or in the near future and just infecting everyone will not help at all.

We also dont know how quickly it mutates - though it must be slower than flu or we'd have noticed changes by now since this debacle has been going on since last december.

Hopefully worst case scenario we'll just all have to have semi regular "booster" vaccine shots once they have working vaccines, and eventually it'll be like polio and measles where so many people are vaccinated that it can't really spread easily and it calms down. Or maybe they'll find another coronavirus very similar, base a vaccine on that, but the antibodies for that virus stick around longer than for covid? Idk this entire paragraph is speculation, but yeah.

TL;DR barricade the fort with Smegs and we'll eat post apocalyptic slop and discuss naming the german shepard.
 
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Thank you! So it sounds like normal flu then, they’ll need an annual covid vaccine? That’s bleeping mental?! Does that mean we can never go back to the old ways?! Sorry to be so dim, here’s a relevant tweet, my brain shrinks with every passing year

View attachment 249917



will read this now thank you, that’s what I just stupidly asked above!!
They didn’t say about it being annual but that’s my guess they said it’s here to stay and we will have to learn to live with it and they see a six month period of getting through this bad bit
 
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What is everyone else having for dinner (I feel like I ask this every day but I love hearing about it!)
Strong Roots quinoa and kale ‘burgers’ topped with hummus in pita bread. Their products are on offer at Ocado now.
 
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Feel like I shouldn’t be saying this after the last few pages of people’s (totally reasonable) worries, but I’m heading out for dinner tonight at a real-life restaurant! Dead excited. Just with one friend, so not a rowdy gathering.

Echoing what a few of you have said, I’ve not seen my parents since March either 🙁 All a bit tit innit.
I think if this is the new normal you have to take the opportunities you can to enjoy yourself just not these mad DGAF rowdy gatherings like you say, ooh enjoy and let us know what you eat
 
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Massively over the top paragraphs below because i genuinely find this interesting and wish i had more time to read up on it. (This is coming from like...nearly a decade old a level biology and a couple of podcasts/sciencey websites i read, so if anyone has more current and in depth knowledge in virology from their job or degree etc feel free to step in and save me from my ignorance)

From what i understand vaccines are either a weakened/dead strain of the virus in question (flu shot) or another virus so similar that the immune system thinks theyre the same disease and will react to the actual virus we want to stop (cowpox to smallpox)

Our bodies produce antibodies to fight disease. They do duck all at the time of actually getting the disease to stop you catching it, but if virus enters your body, something starts cranking these antibodies in trial and error until it works out a shape that fits the virus. Antibodies are all pretty much shaped like the letter Y though and its top two bits are like hands, which grab onto the virus. If the white blood cells see anything covered in antibodies they know its bad news and go in for the kill.

So the first time you get a disease theres a lot of time spent making the exact shape of antibody specialised for this virus but the SECOND time the virus moseys on into your body, your body is like

"its that little tit who made us too sick to go to the work xmas do last year! Get him lads!"

and we already have the 'factories' for that shape of antibodies in place, so it rattles them out much quicker. A bit like a car factory, once they have all the equipment to make a vauxhall corsa or whatever they can just start firing them out, but if they suddenly get told "we need to make ferraris" it might take a while to get a new factory with all the equipment and machine lines up and running. A chickenpox antibody would look at covid and just go "pfft. Not my job."

The flu gets round this by mutating and changing all the time (basically it puts on different glasses and a silly hat), so the science boffins have to basically guess (im sure theres a good analytical model rather than a pure guess) which version of the flu will be round at xmas time, and if they get it wrong you can still get the flu which is why some people still get sick.

And obviously there can be issues when some people's bodies are a bit paranoid and start labelling everything as an intruder - whacking antibodies on completely harmless cells like say, one's own liver, and then the white blood cells start attacking your own body - which is one reason why some people may have to take immunosuppressants - and then with the immune system knocked out theyre vulnerable to genuine threats

It is normal for some immunity loss over time for a lot of diseases (imagine the corsa factories havent needed to make a single corsa in 2 years, body's just like nah clear off we're gonna close most of you and build some overpriced student flats here instead) The weird thing about covid is that the body is maybe shutting down the antibody 'factories' within like 2/3 months which is ridiculouslyquick ???

So people could get it again and body would have to start from scratch making the covid antibody shape again.

I know its a completely new virus so its all up in the air, and my science knowledge is nowhere near deep enough to know WHY antibodies being lost so fast, but i know it means "herd immunity" is not happening now or in the near future and just infecting everyone will not help at all.

We also dont know how quickly it mutates - though it must be slower than flu or we'd have noticed changes by now since this debacle has been going on since last december.

Hopefully worst case scenario we'll just all have to have semi regular "booster" vaccine shots once they have working vaccines, and eventually it'll be like polio and measles where so many people are vaccinated that it can't really spread easily and it calms down. Or maybe they'll find another coronavirus very similar, base a vaccine on that, but the antibodies for that virus stick around longer than for covid? Idk this entire paragraph is speculation, but yeah.

TL;DR barricade the fort with Smegs and we'll eat post apocalyptic slop and discuss naming the german shepard.
I loved your ‘explain it like I’m five’ Ted Talk I’m totally here for it
 
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I loved your ‘explain it like I’m five’ Ted Talk I’m totally here for it
One day I will learn the art of brevity!

sorry if it came across patronising, it's not you it's me. This is literally how I explain everything, with lots of hands waving around irl. My manager has never recovered from our talk about security certificates. Halfway through "imagine you're a bouncer checking ID" I realised he'd already done a Windows 95 and decided it was now safe to shut down

dinner is slow cooked chicken curry!!! Ugly but delicious. Hope you have a lovely meal @MarmiteExtract ! :)

I’m laughing at some of the names of the pads, including Minki!
The tampon pineapple...the mink...This was all JMs elaborate plan for a sanitary product brand deal :eek: 😉
 
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Feel like I shouldn’t be saying this after the last few pages of people’s (totally reasonable) worries, but I’m heading out for dinner tonight at a real-life restaurant! Dead excited. Just with one friend, so not a rowdy gathering.

Echoing what a few of you have said, I’ve not seen my parents since March either 🙁 All a bit tit innit.
I love it! I have gone out for Sunday roasts the last two weeks (carefully) because it’s my fave dinner out. Enjoy every bite and every minute. It’s not us careful frauen who are risking people, it’s the mad bastards out on the lash.

I personally have just about begun to relax a bit? we saw limited family once/twice each and went out for drinks once and to eat twice. Glad I got the stuff in I wanted, it’s still so hard for everyone though. Sending love to everyone!
 
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Massively over the top paragraphs below because i genuinely find this interesting and wish i had more time to read up on it. (This is coming from like...nearly a decade old a level biology and a couple of podcasts/sciencey websites i read, so if anyone has more current and in depth knowledge in virology from their job or degree etc feel free to step in and save me from my ignorance)

From what i understand vaccines are either a weakened/dead strain of the virus in question (flu shot) or another virus so similar that the immune system thinks theyre the same disease and will react to the actual virus we want to stop (cowpox to smallpox)

Our bodies produce antibodies to fight disease. They do duck all at the time of actually getting the disease to stop you catching it, but if virus enters your body, something starts cranking these antibodies in trial and error until it works out a shape that fits the virus. Antibodies are all pretty much shaped like the letter Y though and its top two bits are like hands, which grab onto the virus. If the white blood cells see anything covered in antibodies they know its bad news and go in for the kill.

So the first time you get a disease theres a lot of time spent making the exact shape of antibody specialised for this virus but the SECOND time the virus moseys on into your body, your body is like

"its that little tit who made us too sick to go to the work xmas do last year! Get him lads!"

and we already have the 'factories' for that shape of antibodies in place, so it rattles them out much quicker. A bit like a car factory, once they have all the equipment to make a vauxhall corsa or whatever they can just start firing them out, but if they suddenly get told "we need to make ferraris" it might take a while to get a new factory with all the equipment and machine lines up and running. A chickenpox antibody would look at covid and just go "pfft. Not my job."

The flu gets round this by mutating and changing all the time (basically it puts on different glasses and a silly hat), so the science boffins have to basically guess (im sure theres a good analytical model rather than a pure guess) which version of the flu will be round at xmas time, and if they get it wrong you can still get the flu which is why some people still get sick.

And obviously there can be issues when some people's bodies are a bit paranoid and start labelling everything as an intruder - whacking antibodies on completely harmless cells like say, one's own liver, and then the white blood cells start attacking your own body - which is one reason why some people may have to take immunosuppressants - and then with the immune system knocked out theyre vulnerable to genuine threats

It is normal for some immunity loss over time for a lot of diseases (imagine the corsa factories havent needed to make a single corsa in 2 years, body's just like nah clear off we're gonna close most of you and build some overpriced student flats here instead) The weird thing about covid is that the body is maybe shutting down the antibody 'factories' within like 2/3 months which is ridiculouslyquick ???

So people could get it again and body would have to start from scratch making the covid antibody shape again.

I know its a completely new virus so its all up in the air, and my science knowledge is nowhere near deep enough to know WHY antibodies being lost so fast, but i know it means "herd immunity" is not happening now or in the near future and just infecting everyone will not help at all.

We also dont know how quickly it mutates - though it must be slower than flu or we'd have noticed changes by now since this debacle has been going on since last december.

Hopefully worst case scenario we'll just all have to have semi regular "booster" vaccine shots once they have working vaccines, and eventually it'll be like polio and measles where so many people are vaccinated that it can't really spread easily and it calms down. Or maybe they'll find another coronavirus very similar, base a vaccine on that, but the antibodies for that virus stick around longer than for covid? Idk this entire paragraph is speculation, but yeah.

TL;DR barricade the fort with Smegs and we'll eat post apocalyptic slop and discuss naming the german shepard.
Thanks for this Switch x
I'm finding the whole thing fascinating, in a macbre way.

Back in March my entire office came downwith Covid. 2 people died. Several more were hospitalised and therefore swabbed and tested positive. It also went round both my Girls' schools.
I got 'it' and was terrified as I have several quite severe health issues. I genuinely thought I was going to die. Me and my family isolated (whichturned into 12 weeks quarantine) All of us got really poorly.
I spent a week sweating, hallucinating and hacking up my lungs. I also had to care for Mr Moo and the Mini Moos.
Even after the coughing and temperature went we were laid low for a good fortnight.
Obviously we are all fine now.
As you know, me and one of my minis had a negative test last week (but we are both still mega poorly with all the same symptoms)

The thing is, 2 months ago I had an antibodies test andit came out negative. Docs told me is very possible to have it and not become immune.

Baffling but really intriguing!!!
 
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One day I will learn the art of brevity!

sorry if it came across patronising, it's not you it's me. This is literally how I explain everything, with lots of hands waving around irl. My manager has never recovered from our talk about security certificates. Halfway through "imagine you're a bouncer checking ID" I realised he'd already done a Windows 95 and decided it was now safe to shut down

dinner is slow cooked chicken curry!!! Ugly but delicious. Hope you have a lovely meal @MarmiteExtract ! :)


The tampon pineapple...the mink...This was all JMs elaborate plan for a sanitary product brand deal :eek: 😉
No it like actually taught me things 🤣❤
 
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Thanks for this Switch x
I'm finding the whole thing fascinating, in a macbre way.

Back in March my entire office came downwith Covid. 2 people died. Several more were hospitalised and therefore swabbed and tested positive. It also went round both my Girls' schools.
I got 'it' and was terrified as I have several quite severe health issues. I genuinely thought I was going to die. Me and my family isolated (whichturned into 12 weeks quarantine) All of us got really poorly.
I spent a week sweating, hallucinating and hacking up my lungs. I also had to care for Mr Moo and the Mini Moos.
Even after the coughing and temperature went we were laid low for a good fortnight.
Obviously we are all fine now.
As you know, me and one of my minis had a negative test last week (but we are both still mega poorly with all the same symptoms)

The thing is, 2 months ago I had an antibodies test andit came out negative. Docs told me is very possible to have it and not become immune.

Baffling but really intriguing!!!
So glad you and your loved ones pulled through Moobelle, can't imagine how scary and horrible that was.

It's an awful thing but as you said; also fascinating, it's a bit like being into horror movies and/or true crime I guess, sometimes the things that terrify us are also very compelling to us. The lack of immunity is really scary. With this and the wildfires I half think this is the planet just going "Right I've had enough" and trying to reduce the human population to save itself.

Better times will come, in a few decades hopefully we'll be looking back on this on some kind of VR tattle like "wow 2020 was wild thank god we cured that disease and then all got our flying cars"

*whispers sheepishly* lasagne
Shouldnt that be.....





*whispers hoarsely*
 
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@Switchstreetz that was an amazing explanation, thank you! So informative and not patronising at all. What else can you teach us?!

I had a delicious cheese platter (although one of the cheeses was a blue variety and I’m a proper child who doesn’t like the mouldy aspect, so minus points for that) with lovely freshly baked warm bread dipped in olive oil and vinegars, and a glass of wine. Simple but lovely. And the tube is empty on the way home - bonus!
 
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Massively over the top paragraphs below because i genuinely find this interesting and wish i had more time to read up on it. (This is coming from like...nearly a decade old a level biology and a couple of podcasts/sciencey websites i read, so if anyone has more current and in depth knowledge in virology from their job or degree etc feel free to step in and save me from my ignorance)

From what i understand vaccines are either a weakened/dead strain of the virus in question (flu shot) or another virus so similar that the immune system thinks theyre the same disease and will react to the actual virus we want to stop (cowpox to smallpox)

Our bodies produce antibodies to fight disease. They do duck all at the time of actually getting the disease to stop you catching it, but if virus enters your body, something starts cranking these antibodies in trial and error until it works out a shape that fits the virus. Antibodies are all pretty much shaped like the letter Y though and its top two bits are like hands, which grab onto the virus. If the white blood cells see anything covered in antibodies they know its bad news and go in for the kill.

So the first time you get a disease theres a lot of time spent making the exact shape of antibody specialised for this virus but the SECOND time the virus moseys on into your body, your body is like

"its that little tit who made us too sick to go to the work xmas do last year! Get him lads!"

and we already have the 'factories' for that shape of antibodies in place, so it rattles them out much quicker. A bit like a car factory, once they have all the equipment to make a vauxhall corsa or whatever they can just start firing them out, but if they suddenly get told "we need to make ferraris" it might take a while to get a new factory with all the equipment and machine lines up and running. A chickenpox antibody would look at covid and just go "pfft. Not my job."

The flu gets round this by mutating and changing all the time (basically it puts on different glasses and a silly hat), so the science boffins have to basically guess (im sure theres a good analytical model rather than a pure guess) which version of the flu will be round at xmas time, and if they get it wrong you can still get the flu which is why some people still get sick.

And obviously there can be issues when some people's bodies are a bit paranoid and start labelling everything as an intruder - whacking antibodies on completely harmless cells like say, one's own liver, and then the white blood cells start attacking your own body - which is one reason why some people may have to take immunosuppressants - and then with the immune system knocked out theyre vulnerable to genuine threats

It is normal for some immunity loss over time for a lot of diseases (imagine the corsa factories havent needed to make a single corsa in 2 years, body's just like nah clear off we're gonna close most of you and build some overpriced student flats here instead) The weird thing about covid is that the body is maybe shutting down the antibody 'factories' within like 2/3 months which is ridiculouslyquick ???

So people could get it again and body would have to start from scratch making the covid antibody shape again.

I know its a completely new virus so its all up in the air, and my science knowledge is nowhere near deep enough to know WHY antibodies being lost so fast, but i know it means "herd immunity" is not happening now or in the near future and just infecting everyone will not help at all.

We also dont know how quickly it mutates - though it must be slower than flu or we'd have noticed changes by now since this debacle has been going on since last december.

Hopefully worst case scenario we'll just all have to have semi regular "booster" vaccine shots once they have working vaccines, and eventually it'll be like polio and measles where so many people are vaccinated that it can't really spread easily and it calms down. Or maybe they'll find another coronavirus very similar, base a vaccine on that, but the antibodies for that virus stick around longer than for covid? Idk this entire paragraph is speculation, but yeah.

TL;DR barricade the fort with Smegs and we'll eat post apocalyptic slop and discuss naming the german shepard.
Omg thank you for taking the time to write this out and explain, you must be a teacher surely?! You could do science podcasts for revision, this was so well explained.

But also how bleak we are doomed!
 
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I’m so sorry to hear so many of us are struggling with the new restrictions looming, I feel so lucky that I’ve got some of my family close to me but
Im not sure if any of you remember but I mentioned 2 months ago that my sister Had gone into labour 2 months early. Well, she finally took her baby home today which is such happy news but also makes me sad that because of Covid and her immune system we won’t be able to see her for the foreseeable and can’t hold her at all for at least the next year! Just wanna give my sister and niece a big hug but I’m so happy that she’s healthy and ready to finally go home.

dinner was late tonight because I forced my family to go for a sunset swim -have to take every opportunity in September! Made coconut mung bean dal with turmeric rice, tandoori cauliflower and lots of pickled onions. Looks crap because it was already dark - miss that lovely summer natural light already.

going to settle down and read @Switchstreetz post now, love the breadth of knowledge in this clever cabal!
 

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I’m so sorry to hear so many of us are struggling with the new restrictions looming, I feel so lucky that I’ve got some of my family close to me but
Im not sure if any of you remember but I mentioned 2 months ago that my sister Had gone into labour 2 months early. Well, she finally took her baby home today which is such happy news but also makes me sad that because of Covid and her immune system we won’t be able to see her for the foreseeable and can’t hold her at all for at least the next year! Just wanna give my sister and niece a big hug but I’m so happy that she’s healthy and ready to finally go home.

dinner was late tonight because I forced my family to go for a sunset swim -have to take every opportunity in September! Made coconut mung bean dal with turmeric rice, tandoori cauliflower and lots of pickled onions. Looks crap because it was already dark - miss that lovely summer natural light already!
What a beautiful sunset!!! And curry. I'm so sorry covid is keeping you from your wonderful new niece, when this is over and you get to hold her, it will be such a precious moment, and you will have the rest of your lives to be the most amazing auntie ❤

You're all such incredible people, love that we have such a wide variety of fraus here all with their own skill sets and knowledge, we're like a swiss army knife - there's a maven for every occasion ☺
 
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What a beautiful sunset!!! And curry. I'm so sorry covid is keeping you from your wonderful new niece, when this is over and you get to hold her, it will be such a precious moment, and you will have the rest of your lives to be the most amazing auntie ❤

You're all such incredible people, love that we have such a wide variety of fraus here all with their own skill sets and knowledge, we're like a swiss army knife - there's a maven for every occasion ☺
Oh thats such a lovely thing to say, thank you! And you are absolutely brilliant at explaining things, my grasp of science is abysmal and even I understood that!

Yes such a huge variety yet also think everyone on here is somehow remarkably on the same page when it comes to so many things (especially humour). Isn't it weird to think we have ol' bean rinser Mcgee to thank for bringing us together?!
 
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Oh thats such a lovely thing to say, thank you! And you are absolutely brilliant at explaining things, my grasp of science is abysmal and even I understood that!

Yes such a huge variety yet also think everyone on here is somehow remarkably on the same page when it comes to so many things (especially humour). Isn't it weird to think we have ol' bean rinser Mcgee to thank for bringing us together?!
I know! She really did help the working class folk out after all - by helping dozens upon dozens of people find tattle and the cabal 🤣

Lockdown would have been so much less bearable without the Fraus 💕
 
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at least if this did happen people here could warn me when I am about to get mine, I always forget and forget to buy stuff for it etc :LOL: :LOL: :LOL:


yeh definitely, that was really such a slap in the face. I was SCREAMING at the tv during his interview about it
You need a pineapple jar full of tampons on your bookshelf like JM!

I swear by a mooncup though, so no idea what I could display that in 🤔
 
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