Yes.
I have a very toxic aunt. My mums sister. My mum passed 11 years ago and since then has almost acted like a gatekeeper for that side of the family. She has the ability to sway the entire maternal family who are actually the black sheep from theirs against me whenever she fancies. This yes, sadly includes my grandparents. I have a brother who I barely talk to at all and a sister, they stopped talking to that entire side as teenagers, as they both happen to be gay and found them homophobic, we are all in our 30s now and say I'm silly for letting them back in time after time and have often been angry with me for going back. My mums funeral felt very wild west as all her side of the family wasn't speaking to me because of her bull again. None of the family seem to speak to me unless me and her star to speak again. Thing is, they all witch about what she is like but succumb to her vile ways.
I recently let her back in, I stopped speaking to her years ago, she attacked me on holiday, infront of my children and despite everyone knowing what she is like, still let her cause rifts between everyone so they stop speaking me, I only let her back into my life so I can talk to my nana and grandad again as they are getting really old now.
No one else is really that close. I also have two uncles on that side of the family, one is extremely obnoxious, his daughters we never really knew as he never bothered with them and calls them the most vile names because they wont with him now they are adults. My other uncle is aloof, so is his son.
My dad is great, but hes old school and can appear cold. It took me 36 years to realise that. His parents died when we were kids, his siblings moving to other parts of the country shortly after so never had the opportunity to grow up into adulthood with my cousins.